Exceptional, fully validated antibodies to Ryanodine Receptor Phospho Serine-2808 (RYR2 PS-2808) | Ryanodine Receptor Phospho Serine-2030 (RYR2 PS-2030) | Ryanodine Receptor Phospho Serine-2814 (RYR2 PS-2814)| Ryanodine Receptor DePhospho Serine-2808 (RYR2 DePS-2814). Available as anti-sera or protein A affinity purified antibodies. Lyophilised with stabilizer for economical and environmentally friendly shipment and storage.
Ryanodine receptors (RyRs) are intracellular calcium channels that are expressed in the endoplasmic reticulum or sarcoplasmic reticulum and which open in response to ligand (Ca2+) binding. Three genes exist encoding RYR1 (skeletal muscle distribution), RYR2 (cardiac muscle distribution), and RYR3 (ubiquitous expression). They are key components of excitation contraction coupling in muscle and defects in their function is extremely harmful. RyR function is controlled by a wide variety of allosteric regulators (calmodulin, ATP, cyclic ADPribose, etc.) and by post-translational modification (posphoylation, nitrosylation). Abnormalities in phosphorylation of RyR2 contributes significantly to cardivascular disease (CPVT, heart failure, arrhythmias).
Badrilla was the first company to produce antibodies to phosphorylated forms of RyR2, and these are viewed by leaders in the field as the best, most specific probes available (Huke & Bers (2008) Biochem. Biophys. Res. Comm. 376, 80-85). Badrilla provides antibodies to RyR2 phosphorylated on Ser-2030 (PKA site), Ser-2808 (PKA, CaMKII site), Ser-2814 (CaMKII site) and to dephosphorylated Ser-2808 (PKA, CaMKII site).
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6 Product(s)
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anti-RyR2 Dephospho Serine-2808 (A010-35AP)
£390.47Description: Polyclonal antibody specific to Ser-2808 dephosphorylated RYR2.
Unit Volume: 100 µl
Tested Applications: Western blot (1:5000 dilution), IHC Microscopy (1:100)
Antibody form: Lyophilised rabbit anti-serum (IgG).
Species recognition: all mammalian species, when dephosphorylated on Ser-2808 (or 2809 rabbit)
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anti-RYR2 Phospho Ser-2814 Anti-Serum (A010-31)
£374.06Description: Rabbit Polyclonal anti-Serum specific to Ser-2814 phosphorylated RYR2
Product Data: Link
Unit Volume: 50 µl
Tested Applications: Western blot (1:5000 dilution), IHC Microscopy (1:100 dilution)
Antibody form: Lyophilised rabbit anti-serum (IgG).
Species recognition: All mammalian species, when phosphorylated on Ser-2814 (or Ser-2815 rabbit) Antibody recognises epitope despite single residue difference in epitope between species (V2815I; human vs mouse).
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anti-RYR2 Phospho Serine-2030 IgG (A010-32)
£374.06Description: Polyclonal antibody specific to RYR2 phospho-Ser2030.
Unit Volume: 50 µl
Tested Applications: Western blot (1:5000 dilution)
Antibody form: Lyophilised rabbit anti-serum (IgG).
Species recognition: human, rat, mouse, rabbit, canine and sheep
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anti-RYR2 Phospho Serine-2808 (A010-30AP)
£390.47Description: Polyclonal antibody specific to RYR2 Phospho Serine-2808.
Unit Volume: 100 µl
Tested applications: western blot (1:2000 dilution)
Antibody form: Lyophilised Protein A Affinity Purified Antibody (IgG).
Species recognition: human, rat, mouse, rabbit, canine and sheep
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anti-RYR2 Phospho Serine-2808 Anti-Serum (A010-30)
£374.06Description: Rabbit Polyclonal anti-serum specific to RYR2 phospho Serine-2808.
Unit Volume: 50 µl
Tested applications: Western blot (1:5000 dilution), IHC Microscopy (1:100 dilution)
Antibody form: Lyophilised rabbit anti-serum (IgG).
Species recognition: human, rat, mouse, rabbit, canine and sheep
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anti-RYR2 Phospho Serine-2814 (A010-31AP)
£390.47Description: Affinity Purified Rabbit Polyclonal antibody specific to Ser-2814 phosphorylated RYR2.
Unit Volume: 100 µl
Tested Applications: Western blot (1:2000 dilution)
Antibody form: Lyophilised Protein A Affinity Purified Antibody (IgG).
Species recognition: All mammalian species, when phosphorylated on Ser-2814 (or Ser-2815 rabbit) Antibody recognises epitope despite single residue difference in epitope between species (V2815I; human vs mouse).
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6 Product(s)