Description: Highly specific, well validated Polyclonal anti-sera to SERCA2a (anti-SERCA2a)
Background: SERCA2a is a Ca2+ pump located in the sarcoplasmic reticulum of cardiac and slow-twitch skeletal muscle. The enzyme transports Ca2+ from the cytoplasm into the SR using the hydrolysis of ATP as the energy source for this reaction. Two Ca2+ are transported for each ATP hydrolysed. This Ca2+ transport is the principal means of muscle relaxation in cardiac and slow-twitch skeletal muscle. The activity of SERCA2a is moderated by its interaction with phospholamban. SERCA2a is one isoform of SERCA2: this isoform differs from SERCA2b and SERCA2c at the extreme carboxy terminus only. Antibody A010-20 recognises the C-terminal sequence which distinguishes SERCA2a from SERCA2b and SERCA2c.
Tested applications: Western Blot (1:5000 dilution)
Antibody form: Lyophilised Rabbit anti-serum (IgG).
Species recognition: The antibody reacts with SERCA2a from human, rat, mouse, rabbit, canine, and bovine species