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    SERCA2a pAb serum

    $309.75

    In stock

    Product code: A010-20
    Unit Size: 20 μl

    Description: Highly specific, well validated Polyclonal anti-sera to SERCA2a (anti-SERCA2a)

    Background: SERCA2a is a Ca2+ pump located in the sarcoplasmic reticulum of cardiac and slow-twitch skeletal muscle. The enzyme transports Ca2+ from the cytoplasm into the SR using the hydrolysis of ATP as the energy source for this reaction. Two Ca2+ are transported for each ATP hydrolysed.  This Ca2+ transport is the principal means of muscle relaxation in cardiac and slow-twitch skeletal muscle. The activity of SERCA2a is moderated by its interaction with phospholamban. SERCA2a is one isoform of SERCA2: this isoform differs from SERCA2b and SERCA2c at the extreme carboxy terminus only.  Antibody A010-20 recognises the C-terminal sequence which distinguishes SERCA2a from SERCA2b and SERCA2c. 

    Tested Applications: Western Blot (1:5000 dilution)

    Antibody Form:  Lyophilised Rabbit anti-serum (IgG).

    Species Recognition: The antibody reacts with SERCA2a from human, rat, mouse, rabbit, canine, and bovine species

    Full Publication list: 20 papers

     

    Selected Publications:

    Carbon monoxide exposure enhances arrhythmia after cardiac stress: involvement of oxidative stress. 

    André, L., Gouzi, F., Thireau, J., Meyer, G., Boissiere, J., Delage, M., Abdellaoui, A., Feillet-Coudray, C., Fouret, G., Cristol, J.P., et al. (2011). Basic Res Cardiol 106, 1235-1246.

    Aromatase deficiency confers paradoxical postischemic cardioprotection.

    Bell, J.R., Mellor, K.M., Wollermann, A.C., Ip, W.T., Reichelt, M.E., Meachem, S.J., Simpson, E.R., and Delbridge, L.M. (2011).  Endocrinology 152, 4937-4947.

    Storage Lyophilised: 4 °C Reconstituted:-80 °C
    Epitope/Isoform Alignment No
    Epitope/Species Alignment

    Ep/Sp Alignment

    Data Sheet

    A010-20

    (PDF 219 kB)

    A010-20 lot: 1012-10

    (PDF 499 kB)

    MSDS

    A010-20

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