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    SERCA2a pAb serum


    In stock

    Product code: A010-20
    Unit Size: 20 μl

    Description: Highly specific, well validated Polyclonal anti-sera to SERCA2a (anti-SERCA2a)

    Citations for this product: 17

    Background: SERCA2a is a Ca2+ pump located in the sarcoplasmic reticulum of cardiac and slow-twitch skeletal muscle. The enzyme transports Ca2+ from the cytoplasm into the SR using the hydrolysis of ATP as the energy source for this reaction. Two Ca2+ are transported for each ATP hydrolysed.  This Ca2+ transport is the principal means of muscle relaxation in cardiac and slow-twitch skeletal muscle. The activity of SERCA2a is moderated by its interaction with phospholamban. SERCA2a is one isoform of SERCA2: this isoform differs from SERCA2b and SERCA2c at the extreme carboxy terminus only.  Antibody A010-20 recognises the C-terminal sequence which distinguishes SERCA2a from SERCA2b and SERCA2c. 

    Tested Applications: Western Blot (1:5000 dilution)

    Antibody Form:  Lyophilised Rabbit anti-serum (IgG).

    Species Recognition: The antibody reacts with SERCA2a from human, rat, mouse, rabbit, canine, and bovine species

    Selected produc citations:

    1. PMID: 22617407 | Functional evidence for an active role of B-type natriuretic peptide in cardiac remodelling and pro-arrhythmogenicity.
    2. PMID: 22456325 | A calcium-sensitive promoter construct for gene therapy.
    3. PMID: 22198170 | Fructose diet treatment in mice induces fundamental disturbance of cardiomyocyte Ca2+ handling and myofilament responsiveness.
    4. PMID: 22028441 | Aromatase deficiency confers paradoxical postischemic cardioprotection. 
    5. PMID: 21822772 | Carbon monoxide exposure enhances arrhythmia after cardiac stress: involvement of oxidative stress.

    Did you know? Badrilla products have been cited in over 350 independent publications. For a full listing, visit our citations page.

    Storage Lyophilised: 4 °C Reconstituted:-80 °C
    Epitope/Isoform Alignment No
    Epitope/Species Alignment

    Ep/Sp Alignment

    Datasheet A010-20 Lot 0210-06

    A010-20 Lot 0814-01

    MSDS A010-20

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