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    L-type Ca2+ channel (Cav1.2) (pSer1928) pAb

    $599.00

    In stock

    Product code: A010-70
    Unit Size: 50 µl

    A well validated rabbit polyclonal antibody specific to Serine-1928 phosphorylated Cav1.2 (α1c sub-unit of L-type Ca2+channel)

    Background: The L-type Ca2+ channel (LTCC, or Cav1.2 or dihydropyridine receptor) is a voltage gated Ca2+ channel of the plasma membrane in brain and heart, which is responsible for the influx of Ca2+ to initiate neurotransmitter release (in neurones) or muscle contraction (in cardiac muscle). The channel is controlled by a number of chemical influences including phosphorylation on Ser-1928 by PKA  which enhances ion channel activity. Ser-1928 from rabbit, is conserved across all mammalian species and is thought to be phosphorylated in response to elevated cAMP in these species.

    Tested applications: IHC Microscopy (1:100). Species recognition: all mammalian species, when phosphorylated on Ser-1928.

     

     
    Description Lyophilised rabbit polyclonal anti-serum (A010-70) containing IgG antibody specific for Cav1.2 Phospho Ser-1928 (PKA site).
    Immunogen Synthetic peptide (LGRRAS(PO3H2)FHLE1932) corresponding to amino acids surrounding the phosphorylated serine residue at position 1928 of α1c subunit of Cav1.2 from rabbit conjugated to KLH.
    Isotype IgG
    Purification Raw serum
    Species reactivity The epitope peptide aligns exactly to Human Cav1.2 α1c isoforms 1-23 (See website - Ep/Is alignment). The antibody has been shown to recognise phosphorylated serine-1928 of rat Cav1.2 (α1c), and binding is blocked in the presence of a peptide containing the Phospho Ser-1928 epitope.
    Tested applications IHC microscopy
    Recommended dilution IHC microscopy: 1:100
    Optimization Optimal dilutions to be determined by end user
    Storage Lyophilised antibody is stable at 4°C when stored with desiccant. Reconstitute lyophilised powder in 50 µl of 18 MΩ H2O, aliquot and store frozen at -80°C for 1 year. Avoid freeze - thaw cycles.
    Storage Lyophilised: 4 °C. Reconstituted:-80 °C
    Datasheet A010-70

    MSDS A010-70

    Regulatory statement Product for research use only. Not intended for diagnostic or therapeutic use.

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    DISCLAIMER: Products for research use only (RUO) and are not intended for diagnostic or therapeutic use.

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