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Cardiovascular disease is the single most prevalent cause of death in the United States and Europe. As such, research investigating the pathophysiology of the various forms of heart disease garners billions of dollars of research funding each year. An essential component of this research is focused on the molecular basis of normal heart function. Key to understanding these molecular mechanisms is phospholamban (PLN), an important regulatory protein that embeds within the membrane of the cardiomyocyte sarcoplasmic reticulum (SR). PLN plays a central role in calcium regulation and cardiac relaxation and as such, is a molecule that is deserving of attention and further understanding. Read full article.
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