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    These antibodies have been fully validated by western blotting, and in many cases, tested in immunoflourescence, ELISA and immunoprecipitation assays. In addition to antibodies against cardiovascular targets, we source and re-validate highly specific antibodies from academic leaders. Our aim is to provide products that work first time in the applications you deploy, which accelerate the progress of your research, and which satisfy your expectations in every way.

    Highly specific monoclonal and polyclonal antibodies are pivotal to the success of programs of research. Successful application of each antibody product in Western blot (WB), immunofluorescence microscopy (IF), and functional assays is indicated where we have direct evidence. Antibodies may prove suitable for use in additional formats of immunoassay.

    7 Item(s)

    1. DPc10 Inactive Peptide

      $158.49
      Product code: A010-515

      DPc10 inactive peptide is a 36-residue peptide that differs from DPc10 (Gly2460-Pro2495, rabbit) at one position (R2475S) and represents the sequence of a known CPVT mutant RYR2 domain. This peptide binds weakly or fails to bind to the DPc10 interface and does NOT affect channel function. It serves as a negative control for research projects using DPc10 peptide.  

      Pack size 200µg.

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    2. DPc10 Peptide

      $158.49
      Product code: A010-514

      DPc10 peptide is a 36-residue peptide corresponding to the Gly2460-Pro2495 region of rabbit RyR2. It interacts with RYR2 and provokes abnormal channel activity usually seen in mutant RYR2 channels associated with CPVT. Elevates Ca2+-leak, increases Ca2+-spark activity, is pro-arrhythmic, and provokes hypertrophy in cardiac myocytes.  

      Pack size 200µg.

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    3. DPc10 Peptides Sampler Pack

      $480.00
      Product code: A010-518

      Convenient, cost effective sampler pack containing four DPc10 peptide derivatives (200µg each) as follows:

      1. DPc10 Peptide (Cat. A010-514)
      2. DPc10 Inactive Peptide (Cat. A010-515)
      3. Fluorescein DPc10 Peptide (Cat. A010-516)
      4. Fluorescein DPc10 Inactive Peptide (Cat. A010-517)
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    4. Fluorescein DPc10 Inactive Peptide

      $190.18
      Product code: A010-517

      Fluorescein derivative of the DPc10 inactive peptide, a 36-residue peptide that differs from DPc10 (Gly2460-Pro2495, rabbit) at one position (R2475S) and represents the sequence of a known CPVT mutant RYR2 domain. This peptide binds weakly or fails to bind to the DPc10 interface and does NOT affect channel function. It serves as a negative control for research projects using DPc10 peptide.

      Pack size 200µg.

      Learn More
    5. Fluorescein DPc10 Peptide

      $190.18
      Product code: A010-516

      Fluorescein derivative of DPc10 peptide, a 36-residue peptide corresponding to the Gly2460-Pro2495 region of rabbit RyR2. It interacts with RYR2 and provokes abnormal channel activity usually seen in mutant RYR2 channels associated with CPVT.  Elevates Ca2+-leak, increases Ca2+-spark activity, is pro-arrhythmic, and provokes hypertrophy in cardiac myocytes.

      Pack size 200µg

      Learn More
    6. New-21% PDP3 peptide, cell permeable

      PDP3 peptide, cell permeable

      RRP: $190.18

      Special Price $150.00

      Product code: P010-610

      PDP3 peptide (Ac-RRKRPKRKRKNARVTF-Bpa-EAAEII-NH2; molecular weight 3016.6 g; purity 98.8%) is a cell permeable activator of PP-1. It does so with potentcy of (EC50 176 nM), and its effects are long-lasting as it is slowly metabolised inside cells (due to Bpa moeity). PDP3 has no impact on PP-2A or PP-2B.

      Pack size 1 mg.

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    7. New-21% Stac2-U-domain peptide

      Stac2-U-domain peptide

      RRP: $190.18

      Special Price $150.00

      Product code: P010-700

      Stac2-U-domain peptide (Ac- KVDPVYETLRYGTSLALMNRSS-NH2; molecular weight 2541.9 g; purity 99%) is a cell IMpermeable inhibitor of CA2+-inactivation of Cav1.2. It is derived from the amino acid sequence og human Stac2 (residues 462-483) and when delivered to the cytoplasm of guinea pig ventricular myocytes prolongs the cardiac action potential and recapitulates longQT syndrome.

      Pack size 1 mg.

      Learn More

    7 Item(s)

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    1. Product type: Bioactive peptide Remove This Item
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    1. Bioactive Peptides (7)
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    1. Cav1.2 (1)
    2. PLN (1)
    3. RyR2 (5)
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    DISCLAIMER: Products for research use only (RUO) and are not intended for diagnostic or therapeutic use.

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