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    These antibodies have been fully validated by western blotting, and in many cases, tested in immunoflourescence, ELISA and immunoprecipitation assays. In addition to antibodies against cardiovascular targets, we source and re-validate highly specific antibodies from academic leaders. Our aim is to provide products that work first time in the applications you deploy, which accelerate the progress of your research, and which satisfy your expectations in every way.

    Highly specific monoclonal and polyclonal antibodies are pivotal to the success of programs of research. Successful application of each antibody product in Western blot (WB), immunofluorescence microscopy (IF), and functional assays is indicated where we have direct evidence. Antibodies may prove suitable for use in additional formats of immunoassay.

    Items 1 to 10 of 11 total

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    1. DPc10 Inactive Peptide

      $158.49
      Product code: A010-515

      DPc10 inactive peptide is a 36-residue peptide that differs from DPc10 (Gly2460-Pro2495, rabbit) at one position (R2475S) and represents the sequence of a known CPVT mutant RYR2 domain. This peptide binds weakly or fails to bind to the DPc10 interface and does NOT affect channel function. It serves as a negative control for research projects using DPc10 peptide.  

      Pack size 200µg.

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    2. DPc10 Peptide

      $158.49
      Product code: A010-514

      DPc10 peptide is a 36-residue peptide corresponding to the Gly2460-Pro2495 region of rabbit RyR2. It interacts with RYR2 and provokes abnormal channel activity usually seen in mutant RYR2 channels associated with CPVT. Elevates Ca2+-leak, increases Ca2+-spark activity, is pro-arrhythmic, and provokes hypertrophy in cardiac myocytes.  

      Pack size 200µg.

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    3. DPc10 Peptides Sampler Pack

      $480.00
      Product code: A010-518

      Convenient, cost effective sampler pack containing four DPc10 peptide derivatives (200µg each) as follows:

      1. DPc10 Peptide (Cat. A010-514)
      2. DPc10 Inactive Peptide (Cat. A010-515)
      3. Fluorescein DPc10 Peptide (Cat. A010-516)
      4. Fluorescein DPc10 Inactive Peptide (Cat. A010-517)
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    4. Fluorescein DPc10 Inactive Peptide

      $190.18
      Product code: A010-517

      Fluorescein derivative of the DPc10 inactive peptide, a 36-residue peptide that differs from DPc10 (Gly2460-Pro2495, rabbit) at one position (R2475S) and represents the sequence of a known CPVT mutant RYR2 domain. This peptide binds weakly or fails to bind to the DPc10 interface and does NOT affect channel function. It serves as a negative control for research projects using DPc10 peptide.

      Pack size 200µg.

      Learn More
    5. Fluorescein DPc10 Peptide

      $190.18
      Product code: A010-516

      Fluorescein derivative of DPc10 peptide, a 36-residue peptide corresponding to the Gly2460-Pro2495 region of rabbit RyR2. It interacts with RYR2 and provokes abnormal channel activity usually seen in mutant RYR2 channels associated with CPVT.  Elevates Ca2+-leak, increases Ca2+-spark activity, is pro-arrhythmic, and provokes hypertrophy in cardiac myocytes.

      Pack size 200µg

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    6. Ryanodine receptor 2 (RYR2) (dephoSer2808) pAb

      $655.00
      Product code: A010-35AP

       Polyclonal antibody specific to Ser-2808 dephosphorylated RYR2

      • Suitable for use in Western blot (1:5000 dilution), IHC Microscopy (1:100)
      • Lyophilised rabbit anti-serum (IgG).
      • Species recognition: all mammalian species, when dephosphorylated on Ser-2808 (or 2809 rabbit)
      • 100 µl unit size
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    7. Ryanodine receptor 2 (RYR2) (pSer2030) pAb

      $599.00
      Product code: A010-32

       Polyclonal antibody specific to RYR2 phospho-Ser2030.

      • Suitable for use in Western blot (1:5000 dilution)
      • Antibody form: Lyophilised rabbit anti-serum (IgG)
      • Species recognition: human, rat, mouse, rabbit, canine and sheep
      • 50 µl unit size


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    8. Ryanodine receptor 2 (RYR2) (pSer2808) pAb

      $655.00
      Product code: A010-30AP

      Polyclonal antibody specific to RYR2 phospho serine-2808.

      • Suitable for use in Western blot (1:2000 dilution)
      • Lyophilised Protein A affinity purified pntibody (IgG)
      • Species recognition: human, rat, mouse, rabbit, canine and sheep
      • 100 µl unit size
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    9. Ryanodine receptor 2 (RYR2) (pSer2808) pAb serum

      $599.00
      Product code: A010-30

      Description: Rabbit Polyclonal anti-serum specific to RYR2 phospho Serine-2808.

      Unit Size: 50 µl

      Tested applications: Western blot (1:5000 dilution), IHC Microscopy (1:100 dilution)

      Antibody form: Lyophilised rabbit anti-serum (IgG).

      Species recognition: human, rat, mouse, rabbit, canine and sheep

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    10. Ryanodine receptor 2 (RYR2) (pSer2814) pAb

      $655.00
      Product code: A010-31AP

      Affinity purified rabbit polyclonal antibody specific to Ser-2814 phosphorylated RYR2.

      • Suitable for use in Western blot (1:500 dilution)
      • Lyophilised Protein A affinity purified antibody (IgG)
      • Unit Size: 400 µg
      • Species recognition: all mammalian species, when phosphorylated on Ser-2814 (or Ser-2815 rabbit) 
       

      Antibody recognises epitope despite single residue difference in epitope between species (V2815I; human vs mouse).


      Learn More

    Items 1 to 10 of 11 total

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    1. Target: RyR2 Remove This Item
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    1. Cardiovascular Targets (6)
    2. Bioactive Peptides (5)
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    1. dephoSer2808 (1)
    2. pSer2030 (1)
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    DISCLAIMER: Products for research use only (RUO) and are not intended for diagnostic or therapeutic use.

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