Inherited mutations of the ryanodine receptor (RyR2) cause heart diseases such as CPVT and ARVC. Synthetic peptides corresponding to key subdomains of RyR2 can mimic RyR2 function in these diseases and have been used as useful molecular probes to study structure-function relationships (find publications here). DPc10 peptide is the best studied example of these bioactive peptides. A series of DPc10 peptides is now available from Badrilla to aid your investigation of RyR2 pathologies.
DPc10 peptide is a 36-residue peptide corresponding to the Gly2460-Pro2495 region of rabbit RyR2. It interacts with RYR2 and provokes abnormal channel activity usually seen in mutant RYR2 channels associated with CPVT. Elevates Ca2+-leak, increases Ca2+-spark activity, is pro-arrhythmic, and provokes hypertrophy in cardiac myocytes.
Pack size 200µg.
Learn MorePDP3 peptide (Ac-RRKRPKRKRKNARVTF-Bpa-EAAEII-NH2; molecular weight 3016.6 g; purity 98.8%) is a cell permeable activator of PP-1. It does so with potentcy of (EC50 176 nM), and its effects are long-lasting as it is slowly metabolised inside cells (due to Bpa moeity). PDP3 has no impact on PP-2A or PP-2B.
Pack size 1 mg.
Learn MoreStac2-U-domain peptide (Ac- KVDPVYETLRYGTSLALMNRSS-NH2; molecular weight 2541.9 g; purity 99%) is a cell IMpermeable inhibitor of CA2+-inactivation of Cav1.2. It is derived from the amino acid sequence og human Stac2 (residues 462-483) and when delivered to the cytoplasm of guinea pig ventricular myocytes prolongs the cardiac action potential and recapitulates longQT syndrome.
Pack size 1 mg.
Learn MoreDPc10 inactive peptide is a 36-residue peptide that differs from DPc10 (Gly2460-Pro2495, rabbit) at one position (R2475S) and represents the sequence of a known CPVT mutant RYR2 domain. This peptide binds weakly or fails to bind to the DPc10 interface and does NOT affect channel function. It serves as a negative control for research projects using DPc10 peptide.
Pack size 200µg.
Learn MoreFluorescein derivative of DPc10 peptide, a 36-residue peptide corresponding to the Gly2460-Pro2495 region of rabbit RyR2. It interacts with RYR2 and provokes abnormal channel activity usually seen in mutant RYR2 channels associated with CPVT. Elevates Ca2+-leak, increases Ca2+-spark activity, is pro-arrhythmic, and provokes hypertrophy in cardiac myocytes.
Pack size 200µg
Learn MoreFluorescein derivative of the DPc10 inactive peptide, a 36-residue peptide that differs from DPc10 (Gly2460-Pro2495, rabbit) at one position (R2475S) and represents the sequence of a known CPVT mutant RYR2 domain. This peptide binds weakly or fails to bind to the DPc10 interface and does NOT affect channel function. It serves as a negative control for research projects using DPc10 peptide.
Pack size 200µg.
Learn MoreConvenient, cost effective sampler pack containing four DPc10 peptide derivatives (200µg each) as follows:
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