DPc10 peptide is a 36-residue peptide corresponding to the Gly2460-Pro2495 region of rabbit RyR2. It interacts with RYR2 and provokes abnormal channel activity usually seen in mutant RYR2 channels associated with CPVT. Elevates Ca2+-leak, increases Ca2+-spark activity, is pro-arrhythmic, and provokes hypertrophy in cardiac myocytes.  

Pack size 200µg.

PDP3 peptide (Ac-RRKRPKRKRKNARVTF-Bpa-EAAEII-NH2; molecular weight 3016.6 g; purity 98.8%) is a cell permeable activator of PP-1. It does so with potentcy of (EC50 176 nM), and its effects are long-lasting as it is slowly metabolised inside cells (due to Bpa moeity). PDP3 has no impact on PP-2A or PP-2B.

Pack size 1 mg.

Stac2-U-domain peptide (Ac- KVDPVYETLRYGTSLALMNRSS-NH2; molecular weight 2541.9 g; purity 99%) is a cell IMpermeable inhibitor of CA2+-inactivation of Cav1.2. It is derived from the amino acid sequence og human Stac2 (residues 462-483) and when delivered to the cytoplasm of guinea pig ventricular myocytes prolongs the cardiac action potential and recapitulates longQT syndrome.

Pack size 1 mg.

DPc10 inactive peptide is a 36-residue peptide that differs from DPc10 (Gly2460-Pro2495, rabbit) at one position (R2475S) and represents the sequence of a known CPVT mutant RYR2 domain. This peptide binds weakly or fails to bind to the DPc10 interface and does NOT affect channel function. It serves as a negative control for research projects using DPc10 peptide.  

Pack size 200µg.

Fluorescein derivative of DPc10 peptide, a 36-residue peptide corresponding to the Gly2460-Pro2495 region of rabbit RyR2. It interacts with RYR2 and provokes abnormal channel activity usually seen in mutant RYR2 channels associated with CPVT.  Elevates Ca2+-leak, increases Ca2+-spark activity, is pro-arrhythmic, and provokes hypertrophy in cardiac myocytes.

Pack size 200µg

Fluorescein derivative of the DPc10 inactive peptide, a 36-residue peptide that differs from DPc10 (Gly2460-Pro2495, rabbit) at one position (R2475S) and represents the sequence of a known CPVT mutant RYR2 domain. This peptide binds weakly or fails to bind to the DPc10 interface and does NOT affect channel function. It serves as a negative control for research projects using DPc10 peptide.

Pack size 200µg.