Inherited mutations of the ryanodine receptor (RyR2) cause heart diseases such as CPVT and ARVC. Synthetic peptides corresponding to key subdomains of RyR2 can mimic RyR2 function in these diseases and have been used as useful molecular probes to study structure-function relationships (find publications here). DPc10 peptide is the best studied example of these bioactive peptides. A series of DPc10 peptides is now available from Badrilla to aid your investigation of RyR2 pathologies.
Stac2-U-domain peptide (Ac- KVDPVYETLRYGTSLALMNRSS-NH2; molecular weight 2541.9 g; purity 99%) is a cell IMpermeable inhibitor of CA2+-inactivation of Cav1.2. It is derived from the amino acid sequence og human Stac2 (residues 462-483) and when delivered to the cytoplasm of guinea pig ventricular myocytes prolongs the cardiac action potential and recapitulates longQT syndrome.
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