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    Cardiovascular Targets

    Cardiovascular Targets

    The excitation-contraction coupling of cardiac muscle is a critical to life in most animals, and errors in E-C coupling contribute to important human diseases (arrhythmia, heart failure, cardiac hypertrophy). Highly specific monoclonal and polyclonal antibodies to proteins critical to cardiac muscle excitation-contraction coupling have been assembled. All of these antibodies have been carefully validated for use in western blotting, in addition, some have also been validated for use in immunofluorescence microscopy and in vitro functional assays. Many of these antibodies recognise the site-specific phosphorylation of target proteins and most have been used in numerous publications in the scientific literature.

    Items 1 to 10 of 15 total

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    1. Ryanodine receptor 2 (RYR2) (pSer2808) pAb serum

      $599.00
      Product code: A010-30

      Description: Rabbit Polyclonal anti-serum specific to RYR2 phospho Serine-2808.

      Unit Size: 50 µl

      Tested applications: Western blot (1:5000 dilution), IHC Microscopy (1:100 dilution)

      Antibody form: Lyophilised rabbit anti-serum (IgG).

      Species recognition: human, rat, mouse, rabbit, canine and sheep

      Learn More
    2. Ryanodine receptor 2 (RYR2) (pSer2808) pAb

      $655.00
      Product code: A010-30AP

      Polyclonal antibody specific to RYR2 phospho serine-2808.

      • Suitable for use in Western blot (1:2000 dilution)
      • Lyophilised Protein A affinity purified pntibody (IgG)
      • Species recognition: human, rat, mouse, rabbit, canine and sheep
      • 100 µl unit size
      Learn More
    3. Ryanodine receptor 2 (RYR2) (pSer2814) pAb serum

      $599.00
      Product code: A010-31

      Rabbit polyclonal antiserum specific to Ser-2814 phosphorylated RYR2

      • Suitable for use in Western blot (1:5000 dilution), IHC Microscopy (1:100 dilution)
      • Lyophilised rabbit anti-serum (IgG).
      • Species recognition: All mammalian species, when phosphorylated on Ser-2814 (or Ser-2815 rabbit) *
      • 50 µl unit size

      *Antibody recognises epitope despite single residue difference in epitope between species (V2815I; human vs mouse).

      Learn More
    4. Ryanodine receptor 2 (RYR2) (pSer2814) pAb

      $655.00
      Product code: A010-31AP

      Affinity purified rabbit polyclonal antibody specific to Ser-2814 phosphorylated RYR2.

      • Suitable for use in Western blot (1:2000 dilution)
      • Lyophilised Protein A affinity purified antibody (IgG)
      • Unit Size: 100 µl
      • Species recognition: all mammalian species, when phosphorylated on Ser-2814 (or Ser-2815 rabbit) 
       

      Antibody recognises epitope despite single residue difference in epitope between species (V2815I; human vs mouse).


      Learn More
    5. Ryanodine receptor 2 (RYR2) (pSer2030) pAb

      $599.00
      Product code: A010-32

       Polyclonal antibody specific to RYR2 phospho-Ser2030.

      • Suitable for use in Western blot (1:5000 dilution)
      • Antibody form: Lyophilised rabbit anti-serum (IgG)
      • Species recognition: human, rat, mouse, rabbit, canine and sheep
      • 50 µl unit size


      Learn More
    6. Ryanodine receptor 2 (RYR2) (dephoSer2808) pAb

      $655.00
      Product code: A010-35AP

       Polyclonal antibody specific to Ser-2808 dephosphorylated RYR2

      • Suitable for use in Western blot (1:5000 dilution), IHC Microscopy (1:100)
      • Lyophilised rabbit anti-serum (IgG).
      • Species recognition: all mammalian species, when dephosphorylated on Ser-2808 (or 2809 rabbit)
      • 100 µl unit size
      Learn More
    7. Thapsigargin

      $84.00
      Product code: A010-503

      Potent inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases. Causes ER stress; can be used to induce autophagy in mammalian cells.

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    8. Caffeine

      $42.00
      Product code: A010-504
      Widely used pharmacological probe for studying ryanodine receptor (RyR)-mediated Ca2+ release and cardiac arrhythmias. Learn More
    9. Dantrolene sodium salt

      $67.00
      Product code: A010-505

      Dantrolene inhibits release of Ca2+ from the sarcoplasmic reticulum (SR) via inhibition of ryanodine receptor (RYR) channels. Learn More

    10. Tetracaine hydrochloride

      $75.00
      Product code: A010-506

      Tetracaine inhibits the (Ca2+ + Mg2+)-ATPase from the sarcoplasmic reticulum.

      Learn More

    Items 1 to 10 of 15 total

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    1. Category: Ryanodine Receptor Remove This Item
    Clonality
    1. pAb (6)
    Phosphorylation site
    1. dephoSer2808 (1)
    2. pSer2030 (1)
    3. pSer2808 (2)
    4. pSer2814 (2)
    Product type
    1. Antibody (6)
    2. Bioactive peptide (4)
    3. Inhibitor (5)
    Target
    1. RyR2 (14)
    2. SERCA (1)
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    DISCLAIMER: Products for research use only (RUO) and are not intended for diagnostic or therapeutic use.

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