The excitation-contraction coupling of cardiac muscle is a critical to life in most animals, and errors in E-C coupling contribute to important human diseases (arrhythmia, heart failure, cardiac hypertrophy). Highly specific monoclonal and polyclonal antibodies to proteins critical to cardiac muscle excitation-contraction coupling have been assembled. All of these antibodies have been carefully validated for use in western blotting, in addition, some have also been validated for use in immunofluorescence microscopy and in vitro functional assays. Many of these antibodies recognise the site-specific phosphorylation of target proteins and most have been used in numerous publications in the scientific literature.
Description: Rabbit Polyclonal anti-serum specific to RYR2 phospho Serine-2808.
Unit Size: 50 µl
Tested applications: Western blot (1:5000 dilution), IHC Microscopy (1:100 dilution)
Antibody form: Lyophilised rabbit anti-serum (IgG).
Species recognition: human, rat, mouse, rabbit, canine and sheep
Learn MorePolyclonal antibody specific to RYR2 phospho serine-2808.
Rabbit polyclonal antiserum specific to Ser-2814 phosphorylated RYR2
*Antibody recognises epitope despite single residue difference in epitope between species (V2815I; human vs mouse).
Learn MoreAffinity purified rabbit polyclonal antibody specific to Ser-2814 phosphorylated RYR2.
Antibody recognises epitope despite single residue difference in epitope between species (V2815I; human vs mouse).
Polyclonal antibody specific to RYR2 phospho-Ser2030.
Polyclonal antibody specific to Ser-2808 dephosphorylated RYR2
DPc10 peptide is a 36-residue peptide corresponding to the Gly2460-Pro2495 region of rabbit RyR2. It interacts with RYR2 and provokes abnormal channel activity usually seen in mutant RYR2 channels associated with CPVT. Elevates Ca2+-leak, increases Ca2+-spark activity, is pro-arrhythmic, and provokes hypertrophy in cardiac myocytes.
Pack size 200µg.
Learn MoreDPc10 inactive peptide is a 36-residue peptide that differs from DPc10 (Gly2460-Pro2495, rabbit) at one position (R2475S) and represents the sequence of a known CPVT mutant RYR2 domain. This peptide binds weakly or fails to bind to the DPc10 interface and does NOT affect channel function. It serves as a negative control for research projects using DPc10 peptide.
Pack size 200µg.
Learn MoreFluorescein derivative of DPc10 peptide, a 36-residue peptide corresponding to the Gly2460-Pro2495 region of rabbit RyR2. It interacts with RYR2 and provokes abnormal channel activity usually seen in mutant RYR2 channels associated with CPVT. Elevates Ca2+-leak, increases Ca2+-spark activity, is pro-arrhythmic, and provokes hypertrophy in cardiac myocytes.
Pack size 200µg
Learn MoreConvenient, cost effective sampler pack containing four DPc10 peptide derivatives (200µg each) as follows:
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