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    Cardiovascular Targets

    Cardiovascular Targets

    The excitation-contraction coupling of cardiac muscle is a critical to life in most animals, and errors in E-C coupling contribute to important human diseases (arrhythmia, heart failure, cardiac hypertrophy). Highly specific monoclonal and polyclonal antibodies to proteins critical to cardiac muscle excitation-contraction coupling have been assembled. All of these antibodies have been carefully validated for use in western blotting, in addition, some have also been validated for use in immunofluorescence microscopy and in vitro functional assays. Many of these antibodies recognise the site-specific phosphorylation of target proteins and most have been used in numerous publications in the scientific literature.

    Items 1 to 10 of 19 total

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    1. Calcineurin (pSer197) pAb IgG

      $325.00
      Product code: A010-80AP

      Lyophilised rabbit polyclonal antibody (IgG) preparation conatining antibodies specific for Ser-197 phosphorylated forms Calcineurin.

      • Suitable Western blot (1:200 dilution)
      • Lyophilised total IgG
      • Recognises calcineurin in mouse/rat/human/monkey/other, when phosphorylated on Ser-197
      • Unit size: 100 μl
      Learn More
    2. L-type Ca2+ channel (Cav1.2) (pSer1928) pAb

      $599.00
      Product code: A010-70

      Polyclonal antibody specific to Ser-1928 phosphorylated Cav1.2 (α1c sub-unit of L-type Ca2+-channel).

      • Suitable for use in: IHC Microscopty (1:100 dilution)
      • Lyophilised rabbit anti-serum (IgG)
      • Species recognition: all mammalian species, when phosphorylated on Ser-1928.
      • Unit size: 50 µl
      Learn More
    3. CaMKII (pThr286 or 287) pAb

      $325.00
      Product code: A010-50AP

      Polyclonal antibody specific to α isoform of CaMKII phospho-Thr286 (or Thr287 in β δ, γ isoforms of CaMKII) (CaMKII site).

      • Tested applications: Western blot (1:1000 dilution)
      •  Lyophilised Protein A Affinity Purified Antiboby (IgG).
      • Species Recognition: rat, human and mouse. Expected to react with various isoforms from chicken, cow, pig, rabbit, orangutan, zebrafish, ferret and Xenopus laevis.
      • 50 µl unit size
      Learn More
    4. CaMKII (pThr286 or 287) pAb serum

      $325.00
      Product code: A010-50

      Polyclonal antibody specific to α and  β isoforms of CaMKII phospho-Thr286 (or Thr287 in β).

       

      • Suitable for use in  Western blot (1:5000 dilution)
      • Lyophilised Protein A Affinity Purified Antiboby (IgG).
      • Species Recognition: rat, human and mouse. Expected to react with various isoforms from chicken, cow, pig, rabbit, orangutan, zebrafish, ferret and Xenopus laevis.
      • 20 µl unit size


      Learn More
    5. Ryanodine receptor 2 (RYR2) (dephoSer2808) pAb

      $655.00
      Product code: A010-35AP

       Polyclonal antibody specific to Ser-2808 dephosphorylated RYR2

      • Suitable for use in Western blot (1:5000 dilution), IHC Microscopy (1:100)
      • Lyophilised rabbit anti-serum (IgG).
      • Species recognition: all mammalian species, when dephosphorylated on Ser-2808 (or 2809 rabbit)
      • 100 µl unit size
      Learn More
    6. Ryanodine receptor 2 (RYR2) (pSer2030) pAb

      $599.00
      Product code: A010-32

       Polyclonal antibody specific to RYR2 phospho-Ser2030.

      • Suitable for use in Western blot (1:5000 dilution)
      • Antibody form: Lyophilised rabbit anti-serum (IgG)
      • Species recognition: human, rat, mouse, rabbit, canine and sheep
      • 50 µl unit size


      Learn More
    7. Ryanodine receptor 2 (RYR2) (pSer2814) pAb

      $655.00
      Product code: A010-31AP

      Affinity purified rabbit polyclonal antibody specific to Ser-2814 phosphorylated RYR2.

      • Suitable for use in Western blot (1:500 dilution)
      • Lyophilised Protein A affinity purified antibody (IgG)
      • Unit Size: 400 µg
      • Species recognition: all mammalian species, when phosphorylated on Ser-2814 (or Ser-2815 rabbit) 
       

      Antibody recognises epitope despite single residue difference in epitope between species (V2815I; human vs mouse).


      Learn More
    8. Ryanodine receptor 2 (RYR2) (pSer2814) pAb serum

      $599.00
      Product code: A010-31

      Rabbit polyclonal antiserum specific to Ser-2814 phosphorylated RYR2

      • Suitable for use in Western blot (1:5000 dilution), IHC Microscopy (1:100 dilution)
      • Lyophilised rabbit anti-serum (IgG).
      • Species recognition: All mammalian species, when phosphorylated on Ser-2814 (or Ser-2815 rabbit) *
      • 50 µl unit size

      *Antibody recognises epitope despite single residue difference in epitope between species (V2815I; human vs mouse).

      Learn More
    9. Ryanodine receptor 2 (RYR2) (pSer2808) pAb

      $655.00
      Product code: A010-30AP

      Polyclonal antibody specific to RYR2 phospho serine-2808.

      • Suitable for use in Western blot (1:2000 dilution)
      • Lyophilised Protein A affinity purified pntibody (IgG)
      • Species recognition: human, rat, mouse, rabbit, canine and sheep
      • 100 µl unit size
      Learn More
    10. Ryanodine receptor 2 (RYR2) (pSer2808) pAb serum

      $599.00
      Product code: A010-30

      Description: Rabbit Polyclonal anti-serum specific to RYR2 phospho Serine-2808.

      Unit Size: 50 µl

      Tested applications: Western blot (1:5000 dilution), IHC Microscopy (1:100 dilution)

      Antibody form: Lyophilised rabbit anti-serum (IgG).

      Species recognition: human, rat, mouse, rabbit, canine and sheep

      Learn More

    Items 1 to 10 of 19 total

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    Shop By
    Category
    1. Calcineurin (1)
    2. CaMK II (2)
    3. Cav1.2 (1)
    4. Phospholamban (PLN) (5)
    5. Ryanodine Receptor (6)
    6. SERCA (4)
    Product type
    1. Antibody (19)
    Target
    1. Calcineurin (1)
    2. CaMKII (2)
    3. Cav1.2 (1)
    4. PLN (5)
    5. RyR2 (6)
    6. SERCA (2)
    7. SERCA1 (1)
    8. SERCA2a (1)
    Phosphorylation site
    1. dephoSer2808 (1)
    2. pSer16 (2)
    3. pSer1928 (1)
    4. pSer197 (1)
    5. pSer2030 (1)
    6. pSer2808 (2)
    7. pSer2814 (2)
    8. pSer38 (1)
    9. pThr17 (2)
    10. pThr286 or 287 (2)
    Clonality
    1. mAb (3)
    2. pAb (14)
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    DISCLAIMER: Products for research use only (RUO) and are not intended for diagnostic or therapeutic use.

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