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    β-Dystroglycan

    β-Dystroglycan

    β-dystroglycan is a transmembrane protein and binds to dystrophin (a large rod-like cytoskeletal protein, absent in Duchenne muscular dystrophy patients). Dystrophin, in turn binds to intracellular actin cables. The dystroglycan complex is also serves as a receptor for agrin (regulate agrin-induced acetylcholine receptor clustering at the neuromuscular junction), and Grb2 (a mediator of the Ras-related signal pathway). Phosphorylation of β-dystroglycan on Y890 (mouse or 892 in human) alters the binding partner interactions that the protein makes.

    1 Item(s)

    1. β-Dystroglycan (bDG) (pTyr892) pAb serum

      $325.00
      Product code: A010-200

      Lyophilised rabbit polyclonal anti-serum containing IgG antibody specific for Tyr-892 phosphorylated forms of β-dystroglycan

      • Suitable for use in Western blot (1:500 dilution), IHC Microscopy (1:50 dilution), Immunoprecipitation (1:10 dilution) in RIPA buffer.
      • Lyophilised antiserum.
      • Recognises β-dystroglycan in all mammalian species, when phosphorylated on Tyr-892 (or equivalent)
      • Unit size: 100 μl
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