β-dystroglycan is a transmembrane protein and binds to dystrophin (a large rod-like cytoskeletal protein, absent in Duchenne muscular dystrophy patients). Dystrophin, in turn binds to intracellular actin cables. The dystroglycan complex is also serves as a receptor for agrin (regulate agrin-induced acetylcholine receptor clustering at the neuromuscular junction), and Grb2 (a mediator of the Ras-related signal pathway). Phosphorylation of β-dystroglycan on Y890 (mouse or 892 in human) alters the binding partner interactions that the protein makes.
Product code: A010-200
Lyophilised rabbit polyclonal anti-serum containing IgG antibody specific for Tyr-892 phosphorylated forms of β-dystroglycan
- Suitable for use in Western blot (1:500 dilution), IHC Microscopy (1:50 dilution), Immunoprecipitation (1:10 dilution) in RIPA buffer.
- Lyophilised antiserum.
- Recognises β-dystroglycan in all mammalian species, when phosphorylated on Tyr-892 (or equivalent)
- Unit size: 100 μl