β-dystroglycan is a transmembrane protein and binds to dystrophin (a large rod-like cytoskeletal protein, absent in Duchenne muscular dystrophy patients). Dystrophin, in turn binds to intracellular actin cables. The dystroglycan complex is also serves as a receptor for agrin (regulate agrin-induced acetylcholine receptor clustering at the neuromuscular junction), and Grb2 (a mediator of the Ras-related signal pathway). Phosphorylation of β-dystroglycan on Y890 (mouse or 892 in human) alters the binding partner interactions that the protein makes.
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