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    Exceptional, fully validated antibodies to Calcineurin Phospho Serine-197 (anti-CN PS-197). Lyophilised with stabilizer for economical and environmentally friendly shipment and storage.

    Calcineurin (CN) is a protein phosphatase also known as protein phosphatase 3, PPP3CA, and calcium-dependent serine-threonine phosphatase, and formerly known as protein phosphatase 2B (PP2B).[1] It activates the T cells of the immune system and can be blocked by drugs. Calcineurin activates NFATc (Nuclear Factor of Activated T cell, cytoplasmic), a transcription factor, by dephosphorylating it. The activated NFATc is then translocated into the nucleus, where it upregulates the expression of interleukin 2 (IL-2), which, in turn, stimulates the growth and differentiation of T cell response. Calcineurin is the target of a class of drugs called calcineurin inhibitors, which includes cyclosporine, pimecrolimus and tacrolimus.

    1 Item(s)

    1. Calcineurin (pSer197) pAb IgG

      Product code: A010-80AP

      Lyophilised rabbit polyclonal antibody (IgG) preparation conatining antibodies specific for Ser-197 phosphorylated forms Calcineurin.

      • Suitable Western blot (1:200 dilution)
      • Lyophilised total IgG
      • Recognises calcineurin in mouse/rat/human/monkey/other, when phosphorylated on Ser-197
      • Unit size: 100 μl
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    DISCLAIMER: Products for research use only (RUO) and are not intended for diagnostic or therapeutic use.

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