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    Ryanodine Receptor

    Ryanodine Receptor

    Badrilla provides a comprehensive range of research products to study ryanodine receptor function in health and disease. We have made the original and best antibodies to phosphorylated RYR2 (S2808, S2814, S2030). These are the most widely cited tools used by researchers to follow RYR2 phosphorylation at individual sites, and we display the citations for each antibody on the product page –data that are wholly independent of Badrilla and provided by CiteAb. Leaders in the field are confident of the quality of these antibodies as described in peer-reviewed articles available (Huke & Bers (2008) Biochem. Biophys. Res. Comm. 376, 80-85).

    We have bioactive peptides that mimic dysfunction ofRYR2 normally seen in CPVT-mutant channels(DPc10), fluorescent versions of these. These peptides turn a normal RYR2 channel into an abnormal (CPVT-like) channel and we may facilitate your exploration of disease conditions.

    4 Item(s)

    1. DPc10 Inactive Peptide

      $158.49
      Product code: A010-515

      DPc10 inactive peptide is a 36-residue peptide that differs from DPc10 (Gly2460-Pro2495, rabbit) at one position (R2475S) and represents the sequence of a known CPVT mutant RYR2 domain. This peptide binds weakly or fails to bind to the DPc10 interface and does NOT affect channel function. It serves as a negative control for research projects using DPc10 peptide.  

      Pack size 200µg.

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    2. DPc10 Peptide

      $158.49
      Product code: A010-514

      DPc10 peptide is a 36-residue peptide corresponding to the Gly2460-Pro2495 region of rabbit RyR2. It interacts with RYR2 and provokes abnormal channel activity usually seen in mutant RYR2 channels associated with CPVT. Elevates Ca2+-leak, increases Ca2+-spark activity, is pro-arrhythmic, and provokes hypertrophy in cardiac myocytes.  

      Pack size 200µg.

      Learn More
    3. DPc10 Peptides Sampler Pack

      $480.00
      Product code: A010-518

      Convenient, cost effective sampler pack containing four DPc10 peptide derivatives (200µg each) as follows:

      1. DPc10 Peptide (Cat. A010-514)
      2. DPc10 Inactive Peptide (Cat. A010-515)
      3. Fluorescein DPc10 Peptide (Cat. A010-516)
      4. Fluorescein DPc10 Inactive Peptide (Cat. A010-517)
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    4. Fluorescein DPc10 Peptide

      $190.18
      Product code: A010-516

      Fluorescein derivative of DPc10 peptide, a 36-residue peptide corresponding to the Gly2460-Pro2495 region of rabbit RyR2. It interacts with RYR2 and provokes abnormal channel activity usually seen in mutant RYR2 channels associated with CPVT.  Elevates Ca2+-leak, increases Ca2+-spark activity, is pro-arrhythmic, and provokes hypertrophy in cardiac myocytes.

      Pack size 200µg

      Learn More

    4 Item(s)

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    Contact Us

    Badrilla Ltd.

    15 Queen Square

    Leeds LS2 8AJ

    United Kingdom

     

    +44 (0)7801 730618

     

    info@badrilla.com

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    DISCLAIMER: Products for research use only (RUO) and are not intended for diagnostic or therapeutic use.

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