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Company ProfileBadrilla Ltd, founded in 2003, is an established life science company providing high quality products for the molecular cardiovascular researcher located within major pharmaceutical, biotech, and academic establishments worldwide... Read More
Management TeamProfessor Colyer established Badrilla in 2003, combining substantive entrepeneurial experience with a deep understanding of the cardiovascular research field. The company has grown organically, reinvesting revenues into... Read More
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Ryanodine Receptor
Badrilla provides a comprehensive range of research products to study ryanodine receptor function in health and disease. We have made the original and best antibodies to phosphorylated RYR2 (S2808, S2814, S2030). These are the most widely cited tools used by researchers to follow RYR2 phosphorylation at individual sites, and we display the citations for each antibody on the product page –data that are wholly independent of Badrilla and provided by CiteAb. Leaders in the field are confident of the quality of these antibodies as described in peer-reviewed articles available (Huke & Bers (2008) Biochem. Biophys. Res. Comm. 376, 80-85).
We have bioactive peptides that mimic dysfunction ofRYR2 normally seen in CPVT-mutant channels(DPc10), fluorescent versions of these. These peptides turn a normal RYR2 channel into an abnormal (CPVT-like) channel and we may facilitate your exploration of disease conditions.
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Caffeine
$42.00Product code: A010-504Widely used pharmacological probe for studying ryanodine receptor (RyR)-mediated Ca2+ release and cardiac arrhythmias. Learn More -
Dantrolene sodium salt
$67.00Product code: A010-505Dantrolene inhibits release of Ca2+ from the sarcoplasmic reticulum (SR) via inhibition of ryanodine receptor (RYR) channels. Learn More
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DPc10 Inactive Peptide
$158.49Product code: A010-515DPc10 inactive peptide is a 36-residue peptide that differs from DPc10 (Gly2460-Pro2495, rabbit) at one position (R2475S) and represents the sequence of a known CPVT mutant RYR2 domain. This peptide binds weakly or fails to bind to the DPc10 interface and does NOT affect channel function. It serves as a negative control for research projects using DPc10 peptide.
Pack size 200µg.
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DPc10 Peptide
$158.49Product code: A010-514DPc10 peptide is a 36-residue peptide corresponding to the Gly2460-Pro2495 region of rabbit RyR2. It interacts with RYR2 and provokes abnormal channel activity usually seen in mutant RYR2 channels associated with CPVT. Elevates Ca2+-leak, increases Ca2+-spark activity, is pro-arrhythmic, and provokes hypertrophy in cardiac myocytes.
Pack size 200µg.
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DPc10 Peptides Sampler Pack
$480.00Product code: A010-518Convenient, cost effective sampler pack containing four DPc10 peptide derivatives (200µg each) as follows:
- DPc10 Peptide (Cat. A010-514)
- DPc10 Inactive Peptide (Cat. A010-515)
- Fluorescein DPc10 Peptide (Cat. A010-516)
- Fluorescein DPc10 Inactive Peptide (Cat. A010-517)
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Fluorescein DPc10 Peptide
$190.18Product code: A010-516Fluorescein derivative of DPc10 peptide, a 36-residue peptide corresponding to the Gly2460-Pro2495 region of rabbit RyR2. It interacts with RYR2 and provokes abnormal channel activity usually seen in mutant RYR2 channels associated with CPVT. Elevates Ca2+-leak, increases Ca2+-spark activity, is pro-arrhythmic, and provokes hypertrophy in cardiac myocytes.
Pack size 200µg
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Ranolazine dihydrochloride
$92.00Product code: A010-508Inhibits late sodium and potassium currents and blocks ligand binding to α1, β1, and β2 adrenergic receptors.
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Ryanodine receptor 2 (RYR2) (dephoSer2808) pAb
$655.00Product code: A010-35APPolyclonal antibody specific to Ser-2808 dephosphorylated RYR2
- Suitable for use in Western blot (1:5000 dilution), IHC Microscopy (1:100)
- Lyophilised rabbit anti-serum (IgG).
- Species recognition: all mammalian species, when dephosphorylated on Ser-2808 (or 2809 rabbit)
- 100 µl unit size
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Ryanodine receptor 2 (RYR2) (pSer2030) pAb
$599.00Product code: A010-32Polyclonal antibody specific to RYR2 phospho-Ser2030.
- Suitable for use in Western blot (1:5000 dilution)
- Antibody form: Lyophilised rabbit anti-serum (IgG)
- Species recognition: human, rat, mouse, rabbit, canine and sheep
- 50 µl unit size
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Ryanodine receptor 2 (RYR2) (pSer2808) pAb
$655.00Product code: A010-30APPolyclonal antibody specific to RYR2 phospho serine-2808.
- Suitable for use in Western blot (1:2000 dilution)
- Lyophilised Protein A affinity purified pntibody (IgG)
- Species recognition: human, rat, mouse, rabbit, canine and sheep
- 100 µl unit size
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- pAb (6)
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- dephoSer2808 (1)
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- Antibody (6)
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Leeds Innovation Centre
103 Clarendon Road
Leeds LS2 9DF
United Kingdom
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DISCLAIMER: Products for research use only (RUO) and are not intended for diagnostic or therapeutic use.
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