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    SERCA

    SERCA

    SERCA, or sarco/endoplasmic reticulum Ca2+-ATPase, or SR Ca2+-ATPase, is a calcium ATPase-type P-ATPase, resides in the sarcoplasmic reticulum (SR) within muscle cells. It is a Ca2+ ATPase that transfers Ca2+ from the cytosol of the cell to the lumen of the SR at the expense of ATP hydrolysis during muscle relaxation. There are 3 major domains on the cytoplasmic face of SERCA: the phosphorylation and nucleotide-binding domains, which form the catalytic site, and the actuator domain, which is involved in the transmission of major conformational changes. It seems that, in addition to the calcium-transporting properties, SERCA1 generates heat in some adipocytes. SERCA is normally inhibited by the defective phosphorylation of protein phospholamban, with which it is closely associated. Another protein, calsequestrin, binds calcium within the SR and helps to reduce the concentration of free calcium within the SR, which assists SERCA so that it does not have to pump against such a high concentration gradient. The SR has a much higher concentration of Ca2+(10,000x) inside when compared to the intracellular Ca2+ concentration. The rate at which SERCA moves Ca2+ across the SR membrane can be controlled by phospholamban (PLB/PLN) under β-adrenergic stimulation. When PLB is associated with SERCA, the rate of Ca2+ movement is reduced, upon dissociation of PLB Ca2+ movement increases.

    9 Item(s)

    1. SERCA1 mAb (clone B/4H3)

      $325.00
      Product code: A010-22AP
      Affinity purified Mouse monoclonal antibody to skeletal muscle SERCA1
      • Suitable for use in Western Blot (1:5000 dilution), IHC Microscopy (1:200 dilution)
      • Lyophilised Protein A affinity purified mouse monoclonal IgG
      • Antibody tested on rat and rabbit tissue, but immunogenic peptide aligns with mammalian species, avian, amphibian and fish
      • Unit size: 50 μl
      Learn More
    2. SERCA1/2 mAb (clone Y/1F4)

      $325.00
      Product code: A010-21AP

       Affinity purified Mouse monoclonal antibody to SERCA isoforms 1/2

      • Suitable for use in Western blot (1:2000 dilution), IHC Microscopy (1:50 dilution).
      • Lyophilised Protein A affinity purified mouse monoclonal IgG
      • Tested on rat tissue, but immunogenic peptide aligns with Mammalian, Avian, Amphibian and Fish SERCA
      • Unit size: 50 μl
      Learn More
    3. SERCA2 (pSer38) pAb

      $325.00
      Product code: A010-25AP

      Affinity purified polyclonal antibody specific to Ser-38 phosphorylated forms of SERCA2.

      • Suitable for use in Western Blot (1:1000 dilution)
      • Lyophilised affinity purified IgG
      • Species recognition: Epitope sequence exists in SERCA2 from all mammalian species
      • Unit size: 50 μl
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    4. SERCA2a pAb serum

      $130.00
      Product code: A010-23S

      Rabbit antiserum containing IgG antibodies to SERCA2a protein.

      • Suitable for use in WB (1:20,000 dilution)
      • Lyophilised rabbit serum.
      • Reatcs with all mammalian species 
      • Unit size: 20ul
      Learn More
    5. SERCA2a pAb serum

      $365.00
      Product code: A010-23L

      Rabbit antiserum containing IgG antibodies to SERCA2a protein

      • Suitable for use in WB (1:20,000 dilution)
      • Lyophilised rabbit serum.
      • Reatcs with all mammalian species 
      • Unit size: 20ul
      Learn More
    6. SERCA2a pAb serum

      $325.00
      Product code: A010-20

      Rabbit polyclonal antibody to SERCA2a

      • Suitable for use in Western blot (1:5000 dilution)
      • Raw anti-serum IgG
      • Reacts with SERCA2a from human, rat, mouse, rabbit, canine, and bovine species
      • Unit Size: 20 µl
      Learn More
    7. SERCA2b pAb serum

      $365.00
      Product code: A010-24L

      Rabbit antiserum containing IgG antibodies specific to SERCA2b protein.

      • Suitable for use in WB (1:5,000 dilution)
      • Lyophilised rabbit serum (IgG)
      • Reacts with all mammalian species
      • 100ul unit size
      Learn More
    8. SERCA2b pAb serum

      $130.00
      Product code: A010-24S

      Rabbit antiserum containing IgG antibodies specific to SERCA2b protein.

      • Suitable for use in WB (1:5,000 dilution)
      • Lyophilised rabbit serum (IgG)
      • Reacts with all mammalian species
      • 20ul unit size
      Learn More
    9. Thapsigargin

      $84.00
      Product code: A010-503

      Potent inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases. Causes ER stress; can be used to induce autophagy in mammalian cells.

      Learn More

    9 Item(s)

    Shop By
    Clonality
    1. mAb (2)
    2. pAb (6)
    Phosphorylation site
    1. pSer38 (1)
    Product type
    1. Antibody (8)
    2. Inhibitor (1)
    Target
    1. SERCA (3)
    2. SERCA1 (1)
    3. SERCA2a (3)
    4. SERCA2b (2)
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    DISCLAIMER: Products for research use only (RUO) and are not intended for diagnostic or therapeutic use.

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