JavaScript seems to be disabled in your browser.
You must have JavaScript enabled in your browser to utilize the functionality of this website.

Welcome visitor, you can

For all locations except UK and Europe please use US Dollars

Default welcome msg!

Home
About

Company Profile

Badrilla Ltd, founded in 2003, is an established life science company providing high quality products for the molecular cardiovascular researcher located within major pharmaceutical, biotech, and academic establishments worldwide... Read More

Management Team

Professor Colyer established Badrilla in 2003, combining substantive entrepeneurial experience with a deep understanding of the cardiovascular research field. The company has grown organically, reinvesting revenues into... Read More
Products
Technology
The Blog
Contact

Home
Products
Research Themes
Oxidative Stress and Heart Failure

Back

Oxidative Stress and Heart Failure

Oxidative stress plays an important role in heart failure

Age-related decline of cardiac performance is often associated with oxidative stress and increased levels of free radicals, encompassing both reactive oxygen (ROS) and nitrogen species (RNS). Formation of RNS species is reported in acute myocardiac disorders such as heart failure. These species are metabolites and/or oxidation products of nitrogen monoxide (NO), such as nitrogen dioxide (NO2) and peroxynitrite (ONOO). A hallmark of these species is the conversion of tyrosine to 3-nitrotyrosine (3-NY).

Further reading: Oxidative stress and heart failure. Am J Physiol Heart Circ Physiol. 2011 Dec;301(6):H2181-90 [PubMed]

Which tools do I need? Badrilla is pleased to offer a high integrity monoclonal antibodies and Western blotting starter packs for nitrotyrosine. Ideal reagents for use in the evaluation of oxidative stress in cardiac samples.