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Badrilla Ltd, founded in 2003, is an established life science company providing high quality products for the molecular cardiovascular researcher located within major pharmaceutical, biotech, and academic establishments worldwide... Read More

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Professor Colyer established Badrilla in 2003, combining substantive entrepeneurial experience with a deep understanding of the cardiovascular research field. The company has grown organically, reinvesting revenues into... Read More
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Oxidative Stress and Heart Failure

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Oxidative Stress and Heart Failure

Oxidative stress plays an important role in heart failure

Age-related decline of cardiac performance is often associated with oxidative stress and increased levels of free radicals, encompassing both reactive oxygen (ROS) and nitrogen species (RNS). Formation of RNS species is reported in acute myocardiac disorders such as heart failure. These species are metabolites and/or oxidation products of nitrogen monoxide (NO), such as nitrogen dioxide (NO2) and peroxynitrite (ONOO). A hallmark of these species is the conversion of tyrosine to 3-nitrotyrosine (3-NY).

Further reading: Oxidative stress and heart failure. Am J Physiol Heart Circ Physiol. 2011 Dec;301(6):H2181-90 [PubMed]

Which tools do I need? Badrilla is pleased to offer a high integrity monoclonal antibodies and Western blotting starter packs for nitrotyrosine. Ideal reagents for use in the evaluation of oxidative stress in cardiac samples.

Nitrotyrosine mAb (clone 2E11)

$341.30

Product code: A010-2E11
Affinity purified mouse monoclonal antibody clone 2E11 to nitrotyrosine
- Suitable for use in Western blot (1:2000 dilution)
- Antibody Form: IgG2b
- Protein A affinity purified
- Reacts with Nitrotyrosine either free or incorporated in proteins such as human serum nitro albumin, nitro haemoglobin and nitro insulin. All species
- Unit size: 50 µl
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Nitrotyrosine Western blot starter pack

$441.00

Product code: A010-513

A convenient reagent pack containing a high integrity nitrotyrosine monoclonal antibody and associated positive and negative controls.
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Nitrotyrosine mAb (Clone 6B2)

$341.30

Product code: A010-6B2AP
Affinity purified Mouse monoclonal antibody clone 6B2 to NitroTyrosine (NY)
- Suitable for use in Western blot (1:5000 dilution)
- Protein A affinity purified
- Reacts with Nitrotyrosine either free or incorporated in proteins such as human serum nitro albumin, nitro haemoglobin and nitro insulin. All species
- Unit Size: 20 µl
Learn More