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    Oxidative Stress and Heart Failure

    Oxidative Stress and Heart Failure

    Oxidative stress plays an important role in heart failure

    Age-related decline of cardiac performance is often associated with oxidative stress and increased levels of free radicals, encompassing both reactive oxygen (ROS) and nitrogen species (RNS).  Formation of RNS species is reported in acute myocardiac disorders such as heart failure. These species are metabolites and/or oxidation products of nitrogen monoxide (NO), such as nitrogen dioxide (NO2) and peroxynitrite (ONOO). A hallmark of these species is the conversion of tyrosine to 3-nitrotyrosine (3-NY).  

    Further reading: Oxidative stress and heart failure. Am J Physiol Heart Circ Physiol. 2011 Dec;301(6):H2181-90 [PubMed]

    Which tools do I need? Badrilla is pleased to offer a high integrity monoclonal antibodies and Western blotting starter packs for nitrotyrosine.  Ideal reagents for use in the evaluation of oxidative stress in cardiac samples.

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    DISCLAIMER: Products for research use only (RUO) and are not intended for diagnostic or therapeutic use.

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