Age-related decline of cardiac performance is often associated with oxidative stress and increased levels of free radicals, encompassing both reactive oxygen (ROS) and nitrogen species (RNS). Formation of RNS species is reported in acute myocardiac disorders such as heart failure. These species are metabolites and/or oxidation products of nitrogen monoxide (NO), such as nitrogen dioxide (NO2) and peroxynitrite (ONOO). A hallmark of these species is the conversion of tyrosine to 3-nitrotyrosine (3-NY).
Further reading: Oxidative stress and heart failure. Am J Physiol Heart Circ Physiol. 2011 Dec;301(6):H2181-90 [PubMed]
Which tools do I need? Badrilla is pleased to offer a high integrity monoclonal antibodies and Western blotting starter packs for nitrotyrosine. Ideal reagents for use in the evaluation of oxidative stress in cardiac samples.
Affinity purified mouse monoclonal antibody clone 2E11 to nitrotyrosine
Affinity purified Mouse monoclonal antibody clone 6B2 to NitroTyrosine (NY)
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