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    PLN Degradation

    PLN Degradation

    Metformin increases degradation of phospholamban via autophagy

    David Maclennan's group in Toronto have studied PLN stability and degradation in primary cultured mouse neonatal cardiomyocytes (CMNCs) and mouse hearts. Read the full paper here. Discover other publications from the Maclennan group here.

    Key findings to date:

    • Inhibition of lysosomal and autophagic activities promotes endogenous PLN accumulation, whereas;
    • Acceleration of autophagy with autophagy activator metformin enhances PLN degradation in CMNCs.
    • Pentameric PLN is polyubiquitinylated at the K3 residue
    • Ubiquitinylation is required for p62-mediated selective autophagy trafficking
    • Identifies a mechanism that traffics PLN to the lysosomes for degradation

    Which tools do I need? Badrilla is pleased to offer new panel of reagents to facilitate the study of ubiquitination and autophagy in your experimental workflow.

    7 Item(s)

    1. Thapsigargin

      Product code: A010-503

      Potent inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases. Causes ER stress; can be used to induce autophagy in mammalian cells.

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    2. Metformin hydrochloride

      Product code: A010-500

      Metformin is an antidiabetic agent. Inhibits the synthesis of mTOR resulting in autophagy activation.

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    3. Rapamycin

      Product code: A010-501

      Macrocyclic triene antibiotic that binds to and inhibits the molecular target of rapamycin (mTOR) in complex with FKBP12.

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    4. Bafilomycin A1

      Product code: A010-502

      Highly potent, selective inhibitor of vacuolar type H+-ATPase (V-ATPase). Selective for V-ATPase over other ATP hydrolyzing enzymes

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    5. AccuMarQ Pre-stained Molecular Weight Markers

      Product code: A010-601

      AccuMarQ pre-stained molecular weight markers represent a set of 12 multi-coloured protein standards covering a broad range of molecular weights (10 to 245 kDa).

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    6. ML348

      Product code: A010-701

      Highly potent, selective inhibitor of APT1 (Acyl Palmitoyl Thio-esterase 1). 14 fold greater Selectivity for APT1 over APT2 and other serine hydrolases.

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    7. ML349

      Product code: A010-702

      Highly potent, selective inhibitor of APT2 (Acyl Palmitoyl Thio-esterase 2). 

      Learn More

    7 Item(s)

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    Product type
    1. Activator (2)
    2. Inhibitor (5)
    1. AMPK (1)
    2. mTor (1)
    3. SERCA (1)
    4. V-ATPase (2)

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    DISCLAIMER: Products for research use only (RUO) and are not intended for diagnostic or therapeutic use.

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