• My Account
    My Basket 0

    Badrilla Default welcome msg!


    SUMOylation of SERCA2a

    SUMOylation of SERCA2a

    SUMOylation is essential for preserving the stability and activity of SERCA2a

    Calcium-transporting ATPase ATP2A2, also known as SERCA2a, is a critical ATPase responsible for Ca2+ re-uptake during excitation–contraction (E-C) coupling. Impaired Ca2+ uptake resulting from decreased expression and reduced activity of SERCA2a is a hallmark of heart failure

    Roger Hajjar and co-workers have demonstrated that SUMOylation is essential for preserving the stability and activity of SERCA2a and that levels of SUMO1 are decreased in failing hearts.  They also show in a mouse model of heart failure that gene delivery of SUMO1 can restore heart function to the same degree as delivery of SERCA2a, pointing to SUMO1 as a potential therapeutic candidate for treating heart failure. Read the paper here.

    Key findings to date:

    • SERCA2a is SUMOylated at lysines 480 and 585 
    • SUMOylation is essential for preserving SERCA2a ATPase activity and stability in mouse and human cells
    • Levels of SUMO1 and the SUMOylation of SERCA2a are greatly reduced in failing hearts
    • SUMO1 overexpression in isolated cardiomyocytes augments contractility and accelerates Ca2+ decay
    • SUMOylation is a critical post-translational modification that regulates SERCA2a function 
    • Findings may provide a platform for the design of novel therapeutic strategies for heart failure.

    Which tools do I need? Badrilla is pleased to offer new panel of reagents to facilitate the study of SERCA and SUMOylation in your experimental workflow.

    1 Item(s)

    1. SERCA2 (pSer38) pAb

      Product code: A010-25AP

      Affinity purified polyclonal antibody specific to Ser-38 phosphorylated forms of SERCA2.

      • Suitable for use in Western Blot (1:1000 dilution)
      • Lyophilised affinity purified IgG
      • Species recognition: Epitope sequence exists in SERCA2 from all mammalian species
      • Unit size: 50 μl
      Learn More

    1 Item(s)

    Shop By

    Currently Shopping by:

    1. Phosphorylation site: pSer38 Remove This Item
    Product type
    1. Antibody (1)
    1. SERCA (1)
    1. pAb (1)

    You have no items to compare.

    Contact Us

    Badrilla Ltd.

    15 Queen Square

    Leeds LS2 8AJ

    United Kingdom


    +44 (0)7801 730618



    Useful Links


    DISCLAIMER: Products for research use only (RUO) and are not intended for diagnostic or therapeutic use.

    Badrilla Newsletters

    Sign up for Badrilla newsletters today and receive twice-monthly informative emails relating to cardiovascular research.
    Badrilla enewsletter sign up
    led high bay light