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    The UPS and Heart Failure

    The UPS and Heart Failure

    Increased levels of ubiquitinated proteins are observed in failing hearts

    A functional ubiquitin-proteasome system (UPS) is critical for normal protein turnover and its role is to remove damaged or misfolded proteins via proteolysis of polyubiquitinated species. The accumulation of polyubiquitinated proteins is a hallmark of proteasome dysfunction and is the most commonly used measure for assessing UPS function in human DCM and heart failure.  A consistent observation is that levels of polyubiquitinated proteins are increased in DCM/failing hearts compared with control hearts (find out more about this here). This is typically measured by semi-quantitative Western blot analysis using ubiquitin antibodies.

    Key findings to date:

    • Evidence mounting to link proteasome dysfunction with a variety of cardiac diseases
    • There is significant complexity in the regulation of the UPS in the heart
    • A consistent observation that levels of polyubiquitinated proteins are increased in DCM/failing hearts
    • There is substantial interest in developing novel therapeutics that target ubiquitin conjugation and the UPS

    Further reading: The ubiquitin proteasome system in human cardiomyopathies and heart failure. Am J Physiol Heart Circ Physiol. 2013 May 15; 304(10): H1283–H1293. [PubMed]

    Which tools do I need? Badrilla is pleased to offer new panel of reagents to facilitate the study of the ubiquitin-proteasome system in cardiac samples.

    2 Item(s)

    1. Epoxomicin

      Product code: A010-512

      Proteasome-specific and highly potent, cell permeable, irreversible inhibitor. Reacts with all three active sites of the proteasome, primarily targets chymotrypsin-like activity.

      Learn More
    2. MG132

      Product code: A010-511

      Key reversible, cell-permeable proteasome inhibitor - chymotrypsin-like and caspase-like activity. Calpain / cathepsin inhibitor. Autophagy activator.

      Learn More

    2 Item(s)

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    DISCLAIMER: Products for research use only (RUO) and are not intended for diagnostic or therapeutic use.

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