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    S-Palmitoylation Tools

    S-Palmitoylation Tools

    Palmitoylation has emerged as an important post translational modification regulating protein function, intracellular trafficking and protein-protein as well as protein-lipid interactions. In particular it has generated much interest in the cardiovascular research community since it has been shown to regulate the function of key proteins that contribute to normal Ca2+ cycling and therefore myocyte contraction, as well as G-protein coupled receptors, important modulators of myocardial contractility. 

    Palmitoylation is the covalent attachment of a 16-carbon saturated fatty acid to a cysteine residue within a protein through the formation of a thioester or S-acyl bond.  The process is mediated by a set of enzymes referred to as palmitoyl acyl transferases (PATs) together with the fatty acid donor palmitoyl CoA. There are 24 PAT enzymes which are characterised by a canonical zinc binding motif Asp-His-His-Cys (zDHHC). Furthermore, over 8000 palmitoylated proteins have been identified (a database of these proteins can be found at http://swisspalm.epfl.ch/ ). Palmitoylation can be constitutive in some instances, but can also be dynamic and reversible, in a manner analogous to phosphorylation – the palmitate group being removed by the activity of acyl palmitoyl thioesterases (APTs).

    Learn more about palmitoylation from our knowledge resource : https://badrilla.com/project-landing/

    1 Item(s)

    1. CAPTUREome™ S-Palmitoylated Protein Kit

      Product code: K010-311

      The Badrilla CAPTUREomeTM S-Palmitoylated protein kit is a simple and easy way of determining whether your protein of interest is post translationally modified with a palmitate group. The assay is based on the acyl-RAC (resin assisted capture) method and facilitates, with four simple steps – Block, Cleave, Capture and Analysis -  determination of protein palmitoylation.

      Kit highlights

      • Enables capture of S-palmitoylated proteins.
      • Kit designed to process 4 x 5 biological samples with paired negative controls (i.e. 40 samples in total).
      • Convenient stopping point after blocking treatment.
      • Assay suitable for downstream SDS-PAGE, western blot or mass spectrometry analysis.
      Learn More

    1 Item(s)

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    DISCLAIMER: Products for research use only (RUO) and are not intended for diagnostic or therapeutic use.

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