S-Nitrosylation Tools

Nitric oxide (NO) plays an important role in the regulation of cardiovascular function. In addition to the classic NO activation of the cGMP-dependent pathway, NO can also regulate cell function through protein S-nitrosylation, a redox dependent, thiol-based, reversible posttranslational protein modification that involves attachment of an NO moiety to a nucleophilic protein sulfhydryl group.
A better understanding of the mechanisms regulating protein S-nitrosylation will provide us new therapeutic insights and targets for intervention in cardiovascular disease. Badrilla offers a growing range of antibodies and detection kits to support your nitric oxide and S-nitrosylaltion research projects; further details for each of these products can be found below.
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$368.00
Product code: A010-105
A convenient and easy-to-use kit incorporating a modification of the “biotin-switch” method to allow for the direct visualisation of S-nitrosylated proteins in whole cells or tissues, as well as by western blot analysis.
- A modified ‘biotin-switch’ assay
- Labels all S-nitrosylated sites in sample ('omics')
- DETECT S-NO proteins in whole cells, tissues or lysates
- Colourimetric or fluorimetric detection
- Sufficient reagents for 3 x 20 samples
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$341.30
Product code: A010-2E11
Affinity purified mouse monoclonal antibody clone 2E11 to nitrotyrosine
- Suitable for use in Western blot (1:2000 dilution)
- Antibody Form: IgG2b
- Protein A affinity purified
- Reacts with Nitrotyrosine either free or incorporated in proteins such as human serum nitro albumin, nitro haemoglobin and nitro insulin. All species
- Unit size: 50 µl
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$341.30
Product code: A010-6B2AP
Affinity purified Mouse monoclonal antibody clone 6B2 to NitroTyrosine (NY)
- Suitable for use in Western blot (1:5000 dilution)
- Protein A affinity purified
- Reacts with Nitrotyrosine either free or incorporated in proteins such as human serum nitro albumin, nitro haemoglobin and nitro insulin. All species
- Unit Size: 20 µl
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$441.00
Product code: A010-513
A convenient reagent pack containing a high integrity nitrotyrosine monoclonal antibody and associated positive and negative controls.
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