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Badrilla Ltd, founded in 2003, is an established life science company providing high quality products for the molecular cardiovascular researcher located within major pharmaceutical, biotech, and academic establishments worldwide... Read More

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Professor Colyer established Badrilla in 2003, combining substantive entrepeneurial experience with a deep understanding of the cardiovascular research field. The company has grown organically, reinvesting revenues into... Read More
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Residue Modification
S-Nitrosylation Tools

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S-Nitrosylation Tools

Nitric oxide (NO) plays an important role in the regulation of cardiovascular function. In addition to the classic NO activation of the cGMP-dependent pathway, NO can also regulate cell function through protein S-nitrosylation, a redox dependent, thiol-based, reversible posttranslational protein modification that involves attachment of an NO moiety to a nucleophilic protein sulfhydryl group.

A better understanding of the mechanisms regulating protein S-nitrosylation will provide us new therapeutic insights and targets for intervention in cardiovascular disease. Badrilla offers a growing range of antibodies and detection kits to support your nitric oxide and S-nitrosylaltion research projects; further details for each of these products can be found below.

DETECTome™ S-nitrosylated protein kit

$368.00

Product code: A010-105
A convenient and easy-to-use kit incorporating a modification of the “biotin-switch” method to allow for the direct visualisation of S-nitrosylated proteins in whole cells or tissues, as well as by western blot analysis.
- A modified ‘biotin-switch’ assay
- Labels all S-nitrosylated sites in sample ('omics')
- DETECT S-NO proteins in whole cells, tissues or lysates
- Colourimetric or fluorimetric detection
- Sufficient reagents for 3 x 20 samples
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Nitrotyrosine mAb (clone 2E11)

$325.00

Product code: A010-2E11
Affinity purified mouse monoclonal antibody clone 2E11 to nitrotyrosine
- Suitable for use in Western blot (1:2000 dilution)
- Antibody Form: IgG2b
- Protein A affinity purified
- Reacts with Nitrotyrosine either free or incorporated in proteins such as human serum nitro albumin, nitro haemoglobin and nitro insulin. All species
- Unit size: 50 µl
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Nitrotyrosine mAb (Clone 6B2)

$325.00

Product code: A010-6B2AP
Affinity purified Mouse monoclonal antibody clone 6B2 to NitroTyrosine (NY)
- Suitable for use in Western blot (1:5000 dilution)
- Protein A affinity purified
- Reacts with Nitrotyrosine either free or incorporated in proteins such as human serum nitro albumin, nitro haemoglobin and nitro insulin. All species
- Unit Size: 20 µl
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Nitrotyrosine Western blot starter pack

$420.00

Product code: A010-513

A convenient reagent pack containing a high integrity nitrotyrosine monoclonal antibody and associated positive and negative controls.
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