Fluorescein-DPc10 peptide is fluorescein labelled 36-residue peptide corresponding to the Gly2460-Pro2495 region of rabbit RyR2. It interacts with RyR2 and provokes abnormal channel activity usually seen in mutant RYR2 channels associated with CPVT.
Synthetic peptide, sequence 5Flu-GFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLP, derived from a CPVT-mutant form of RYR2 (residues (Gly2460-Pro2495, rabbit). Formula weight 4462.155: 5-Carboxyfluorescein at N-terminus, free C-terminus, trifluoroacetate counter ions.
95% pure (HPLC reverse phase C18 column 100A 4.6 x 150mm column, gradient from 10% – 90% acetonitrile, in 15 minutes. 60 degC). Yellow powdered solid.
200 μg net peptide weight
Soluble in dimethylsulphoxide
Store as supplied at -20°C for up to 1 year. Store desiccated. Make fresh solutions prior to use.
Product for research use only. Not intended for diagnostic or therapeutic use.