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Badrilla Ltd, founded in 2003, is an established life science company providing high quality products for the molecular cardiovascular researcher located within major pharmaceutical, biotech, and academic establishments worldwide... Read More

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Professor Colyer established Badrilla in 2003, combining substantive entrepeneurial experience with a deep understanding of the cardiovascular research field. The company has grown organically, reinvesting revenues into... Read More
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Bioactive Peptides

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Bioactive Peptides

Useful molecular probes to study structure-function relationships in RyR2

Inherited mutations of the ryanodine receptor (RyR2) cause heart diseases such as CPVT and ARVC. Synthetic peptides corresponding to key subdomains of RyR2 can mimic RyR2 function in these diseases and have been used as useful molecular probes to study structure-function relationships (find publications here). DPc10 peptide is the best studied example of these bioactive peptides. A series of DPc10 peptides is now available from Badrilla to aid your investigation of RyR2 pathologies.

DPc10 Peptide

$166.40

Product code: A010-514

DPc10 peptide is a 36-residue peptide corresponding to the Gly2460-Pro2495 region of rabbit RyR2. It interacts with RYR2 and provokes abnormal channel activity usually seen in mutant RYR2 channels associated with CPVT. Elevates Ca2+-leak, increases Ca2+-spark activity, is pro-arrhythmic, and provokes hypertrophy in cardiac myocytes.

Pack size 200µg.
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DPc10 Inactive Peptide

$166.40

Product code: A010-515

DPc10 inactive peptide is a 36-residue peptide that differs from DPc10 (Gly2460-Pro2495, rabbit) at one position (R2475S) and represents the sequence of a known CPVT mutant RYR2 domain. This peptide binds weakly or fails to bind to the DPc10 interface and does NOT affect channel function. It serves as a negative control for research projects using DPc10 peptide.

Pack size 200µg.
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Fluorescein DPc10 Peptide

$190.18

Product code: A010-516

Fluorescein derivative of DPc10 peptide, a 36-residue peptide corresponding to the Gly2460-Pro2495 region of rabbit RyR2. It interacts with RYR2 and provokes abnormal channel activity usually seen in mutant RYR2 channels associated with CPVT. Elevates Ca2+-leak, increases Ca2+-spark activity, is pro-arrhythmic, and provokes hypertrophy in cardiac myocytes.

Pack size 200µg
Learn More
Fluorescein DPc10 Inactive Peptide

$190.18

Product code: A010-517

Fluorescein derivative of the DPc10 inactive peptide, a 36-residue peptide that differs from DPc10 (Gly2460-Pro2495, rabbit) at one position (R2475S) and represents the sequence of a known CPVT mutant RYR2 domain. This peptide binds weakly or fails to bind to the DPc10 interface and does NOT affect channel function. It serves as a negative control for research projects using DPc10 peptide.

Pack size 200µg.
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DPc10 Peptides Sampler Pack

$480.00

Product code: A010-518
Convenient, cost effective sampler pack containing four DPc10 peptide derivatives (200µg each) as follows:
1. DPc10 Peptide (Cat. A010-514)
2. DPc10 Inactive Peptide (Cat. A010-515)
3. Fluorescein DPc10 Peptide (Cat. A010-516)
4. Fluorescein DPc10 Inactive Peptide (Cat. A010-517)
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